Impact of directly observed treatment on tuberculosis

This chapter will review the epidemiology, pathogenesis, management, and prevention of TB in the setting of HIV infection. Increasing data demonstrate that antiretroviral therapy ART is effective in reducing the risk of TB, even in persons with higher CD4 cell counts. Surviving tubercle bacilli multiply within the macrophage and eventually undergo hematogenous spread to other areas of the body. DNA fingerprinting on paired isolates of M tuberculosis from 17 patients who repeatedly had positive cultures at a single hospital in New York City found 4 patients to have acquired a new, drug-resistant strain of M tuberculosis through exogenous reinfection, probably as a result of nosocomial transmission.

Impact of directly observed treatment on tuberculosis

Correspondence to Fentie Ambaw email: Bulletin of the World Health Organization ; Evidence on the impact of comorbid depression in tuberculosis is scarce.

Impact of directly observed treatment on tuberculosis

One study did analyse the relationship between depression and death or treatment discontinuation in people with tuberculosis, 13 but we were unable to identify any study that disaggregated these outcomes. Other studies assessed disability 14 and quality of life 15 cross-sectionally or investigated changes from baseline in these variables after tuberculosis treatment.

The aim of this study was to examine the impact of comorbid depression on treatment outcomes in people with tuberculosis in Ethiopia and on their health-related quality of life and level of disability. Methods Between December and Julywe conducted a prospective observational study of people who were newly diagnosed with tuberculosis at 14 primary health-care centres in south central i.

Bahir Dar zone Ethiopia. Two centres were hospitals and 12 were health centres. Facilities were eligible for inclusion if they had staff trained in mhGAP, including the detection and treatment of depression.

Standardized treatment, with supervision and patient support An effective drug supply and management system Monitoring and evaluation system, and impact measurement. The five elements of DOTS. DOTS remains at the heart of the Stop TB basic components of DOTS are described and discussed here. Element 1 Political . The problems of drug resistant TB, HIV co-infection, and the social costs of TB in India are staggering. With an estimated annual incidence of 99, cases of MDR–TB (1), the highest in the world, drug resistant TB is a serious threat to control of TB in India.

Trained nurse research assistants provided those willing to participate with detailed information and obtained written informed consent or witnessed a thumb print at data collection. In Ethiopia, all people with newly diagnosed tuberculosis are treated using the directly observed treatment, short course DOTS approach: Other treatment variables were treatment success, treatment failure and death due to any cause.

Impact of directly observed treatment on tuberculosis

Treatment was defined as successful if either the patient was cured i. The study protocol has been published elsewhere. Disability was assessed using the interviewer-administered version of the item WHO Disability Assessment Schedule, version 2.

Our exposure variable was probable depression which was identified using the nine-item version of the Patient Health Questionnaire and defined conservatively as a score of 10 or above.

Data on these variables were obtained at baseline using a structured questionnaire. The duration of tuberculosis symptoms before diagnosis was self-reported by participants at baseline and information on the type of tuberculosis infection i. The presence of any diagnosed comorbid chronic illnesses was also reported by participants themselves and whether or not they had an HIV infection, was recorded in tuberculosis registers.

Bulletin of the World Health Organization

We estimated the association between probable depression at baseline and treatment default, treatment success and death using multivariate Poisson regression analysis with a robust variance estimator and present the results as risk ratios.

We did not perform multivariate analysis for treatment failure because there were only six cases. To examine the change in health-related quality-of-life and disability scores between tuberculosis diagnosis and the end of antituberculosis treatment, we used a multilevel, mixed-effects, generalized linear model to fit data from the three measurement times i.

The analysis was performed using Stata version Results In total, people were recruited. However, as 9 people were subsequently found to have been misdiagnosed with tuberculosis, the study analysis included data on only Face-to-face follow up assessments were conducted with The five elements of DOTS.

DOTS remains at the heart of the Stop TB basic components of DOTS are described and discussed here.


Element 1 Political . *QVAR MDI=QVAR Inhalation Aerosol. Other adverse reactions that occurred in clinical trials using QVAR REDIHALER with an incidence of 1% to 3% and which occurred at a greater incidence than placebo were back pain, headache, pain, nausea and cough.

Tuberculosis management refers to the medical treatment of the infectious disease tuberculosis (TB).. The standard "short" course treatment for TB is isoniazid (along with pyridoxal phosphate to obviate peripheral neuropathy caused by isoniazid), rifampicin (also known as rifampin in the United States), pyrazinamide, and ethambutol for two months, then isoniazid and rifampicin alone for a.

Directly observed therapy is now the standard for all patients receiving therapy for tuberculosis through the department (more than 99 percent of all patients being treated in the state). Targeted Tuberculin Testing and Treatment of Latent Tuberculosis Infection ATS/CDC Statement Committee on Latent Tuberculosis Infection Membership List, June Tuberculosis of spine or TB spine or spinal TB was first described by Percivall Pott.

He noted this as a painful kyphotic deformity of the spine associated with then condition is also referred to as Pott’s disease or Pott’s spine.

WHO | Promoting adherence to treatment for tuberculosis: the importance of direct observation